tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-[1]benaepin-2-one-1-acetate tartrate

CAS No.：117770-66-8

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-[1]benaepin-2-one-1-acetate tartrate Basic information

Product Name:	tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-[1]benaepin-2-one-1-acetate tartrate
Synonyms:	tert-butyl 2-(3-amino-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl)acetate,2,3-dihydroxybutanedioic acid;1H-1-Benzazepine-1-acetic acid, 3-aMino-2,3,4,5-tetrahydro-2-oxo-, 1,1-diMethylethyl ester, (3S)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) (9CI);(S)-tert-Butyl 2-(3-aMino-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetate (2R,3R)-2,3-dihydroxysuccinate;tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-[1]benaepin-2-one-1-acetate tartrate;T-BUTYL 3S-AMINO-2,3,4,5-TETRAHYDRO-1H-1BENAEPIN-2-ONE-1-ACETATE-TARTRATE;tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-[1]benaepin-2-one-...
CAS:	117770-66-8
MF:	C16H22N2O3.C4H6O6
MW:	440.446
EINECS:	1533716-785-6
Product Categories:
Mol File:	117770-66-8.mol

tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-[1]benaepin-2-one-1-acetate tartrate Chemical Properties

Melting point

190°C (dec.)

Safety Information

MSDS Information

tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-[1]benaepin-2-one-1-acetate tartrate Usage And Synthesis

Preparation

The preparation of the tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-benaepin-2-one-1-acetate tartrate is as follows:Chiral Resolution Of Highly Pure (+1-T-BUTYLOX CARBONYLMETHYL-3-AMINO- 2, 3, 4N5-TETRAHYDRO-LH-[L] BENZAZEPIN-2-ONE USING Tartaric Acid Part A: Preparation of Highly Pure (S)-L-T-BUTYLOXYCARBONYLMETHYL-3-AMINO- 2,3, 4, 5-Tetrahydro-lh- [l] Benzazepin-2-One Tartrate Salt of Formula V Highly pure 1-t-butyloxycarbonylmethyl-3-amino-2, 3, 4, 5-TETRAHYDRO-LH- BENZAZEPIN-2-ONE of Formula II (5.0 g, 17.24 mmol) was heated in ethanol (12.5 ml) at 50-55°C for 25 minutes. The temperature was further raised to 60-65°C and to this was added a solution of L- (+)-tartaric acid (1.8g, 11.9mmol) in ethanol (7.5ml). The reaction mixture was stirred for 24 hours at 60-65°C, allowed to cool to 35-37°C and filtered at the same temperature to afford the crude product (2.75g, 72%). This was suspended in alcohol (11ml) and stirred at 62-65°C for 3 hours, allowed to cool to 45-47°C and filtered to afford the title compound. Yield: 2.55 g, 93% Purity: 99.87%

tert-Butyl 3S-amino-2,3,4,5-tetrahydro-1H-[1]benaepin-2-one-1-acetate tartrate Preparation Products And Raw materials

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873