Darunavir

Overview

Darunavir is a second generation protease inhibitor that targets the HIV-1 protease. It demonstrates extremely potent activity against the infectivity and replication of various strains of HIV-1, including several that are resistant to first generation protease inhibitors (IC50s = 3-30 nM). Darunavir has been reported to inhibit both cell-free diffusion and cell-to-cell spread of HIV-1 with IC50 values of 2.5 and 2.8 nM, respectively.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Infection | HIV

Product Information

• Catalog No.: B0084-062615
• CAS No.: 206361-99-1
• Molecular Formula: C27H37N3O7S
• Molecular Weight: 547.67
• Purity: ≥98%
• Storage: Powder : -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
• Solubility: In Vitro : DMSO : ≥ 100 mg/mL(182.60 mM) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

Source

Original product source