Cyclopamine

Overview

Cyclopamine (11-deoxojervine) is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

Application

Products > Drug Discovery > Impurities > Anti-Infectives > Cyclopamine and Impurities | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B0084-068953
• CAS No.: 4449-51-8
• Molecular Formula: C27H41NO2
• Molecular Weight: 411.62
• Purity: >98%
• Storage: Store at -20°C
• Solubility: Soluble in Chloroform, Dichloromethane, Ethanol (20 mg/mL ), DMSO (4 mg/ml), DMF (10 mg/mL)

Source

Original product source