Irinotecan EP Impurity E (SN-38)

Overview

An impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. It inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. Source summary: SN-38 is an active metabolite of irinotecan and a potent ADC cytotoxin targeting topoisomerase I in cancer cells.

Application

Products > Drug Discovery > Impurities > Anti-Neoplastic > Irinotecan and Impurities | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B0084-099455
• CAS No.: 86639-52-3
• Molecular Formula: C22H20N2O5
• Molecular Weight: 392.40
• Purity: ≥95%
• Storage: -20 - 0°C in dark, sealed.
• Solubility: Soluble in DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)

Source

Original product source