Disodium (R)-2-Hydroxyglutarate

Overview

Disodium (R)-2-Hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM. In U-87MG cells, (R)-2-Hydroxyglutarate acts as a weak antagonist of α-KG to inhibit α-KG-dependent histone demethylases and increase dimethylation on both H3K9 and H3K79. Source summary: Disodium (R)-2-Hydroxyglutarate is a metabolic intermediate used in cancer metabolism and enzymatic pathway studies. Explore this compound today!

Application

Products > Drug Discovery > Inhibitor > Other Inhibitors | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B0084-159285
• CAS No.: 103404-90-6
• Molecular Formula: C5H6Na2O5
• Molecular Weight: 192.08
• Purity: 98%
• Storage: 3 years -20°C powder; 6 months -80°C in solvent
• Solubility: Soluble to 38mg/mL in warmed water; Soluble to < 1mg/mL in DMSO; Soluble to < 1mg/mL in ethanol

Source

Original product source