Cobicistat

Overview

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate.

Application

Products > Drug Discovery > Impurities > Anti-Hiv > Cobicistat and Impurities | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B0084-456314
• CAS No.: 1004316-88-4
• Molecular Formula: C40H53N7O5S2
• Molecular Weight: 776.028
• Purity: 98%
• Storage: Powder : -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
• Solubility: In Vitro : DMSO : 250 mg/mL(322.16 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.08 mg/mL (2.68 mM); Clear solution

Source

Original product source