EED-226

Overview

EED-226 is a novel allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC50 = 23.4 nM when the substrate is H3K27me0 peptide and IC50 = 53.5 nM when the substrate is mononucleosom). EED-226 induces a conformational change via binding EED which invalidates PRC2 activity. PRC2 plays pivotal roles in transcriptional regulation. EED-226 has the potential to treat PRC2-dependent cancers, such as human lymphoma xenograft tumors.

Application

Products > Drug Discovery > Inhibitor > Other Inhibitors | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B0084-484681
• CAS No.: 2083627-02-3
• Molecular Formula: C17H15N5O3S
• Molecular Weight: 369.4
• Purity: 98%
• Storage: Store in a cool and dry place and at 0-4 °C for short term (days to weeks) or -66 °C for long term (months to years).
• Solubility: Soluble in DMSO.

Source

Original product source