Cisapride

Overview

Cisapride is a drug that increases motility in the upper gastrointestinal tract and is used as a Gastroprokinetic. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. It is also a potent human ether-à-go-go-related gene (hERG) potassium channel inhibitor. It showed higher inhibitory effects on a hERG current with IC50 of 9.4 × 10-9 M in vitro. It inhibited Kv4.3 in a concentration-dependent manner with IC50 values of 9.8 uM. It could not bring about more colitis damages through 5HT(4) receptors. It was discovered by Janssen Pharmaceutica in 1980. It has been withdrawn from the market.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cardiovascular and blood system | 5-HT Receptor

Product Information

• Catalog No.: B2693-077798
• CAS No.: 81098-60-4
• Molecular Formula: C23H29ClFN3O4
• Molecular Weight: 465.95
• Purity: >99 %
• Storage: Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
• Solubility: 10 mM in H2O (free soluble)

Source

Original product source