Deoxyandrographolide

Overview

Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees. It could potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells. It controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. It was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism. It reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microM. It reduced PAF-induced calcium flux in the presence of extracellular calcium. It mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism.

Application

Products > Chemistry > Natural Compounds | Products > Drug Discovery > Inhibitor | Diterpenoids

Product Information

• Catalog No.: B2693-098584
• CAS No.: 79233-15-1
• Molecular Formula: C20H30O4
• Molecular Weight: 334.45
• Purity: >98%
• Storage: -20°C Freezer
• Solubility: 10 mM in DMSO

Source

Original product source