[Pyr1]-Apelin-13

Overview

[Pyr1]-Apelin-13 is the highly potent pyroglutamylated form of apelin-13, which is an endogenous ligand of the G protein-coupled APJ receptor with EC50 value of 0.37 nM. It is the major apelin form in human plasma and heart, which the N-terminal glutamine residue is cyclized to pyroglutamic acid. It exhibits higher APJ agonist potency than Apelin-13. It has antipyretic and vasoconstrictor effects in vitro and in vivo. It is widely used for studying APJ-mediated cellular and physiological functions both in cultures and in animals in vivo. It is reactive toward human, rat, bovine and murine species. Sequence: XRPRLSHKGPMPF Source summary: [Pyr1]-Apelin-13 is a potent peptide involved in cardiovascular and metabolic research, offering insights into receptor binding and signaling pathways. Inquire now for advanced studies!

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Cardiovascular and blood system | Apelin Receptors

Product Information

• Catalog No.: B2693-102441
• CAS No.: 217082-60-5
• Molecular Formula: C69H108N22O16S
• Molecular Weight: 1533.81
• Purity: 98%
• Storage: Store at -20°C

Source

Original product source