PF-8380

CAS No.：1144035-53-9
Grade：≥95%
Formula：C22H21Cl2N3O5
M.W.：478.33
Solvent：Soluble in DMSO

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

PF-8380 blocks inflammation-induced LPA synthesis. PF-8380 works both in vitro and in vivo through direct inhibition of autotaxin. In human whole blood PF-8380 inhibited autotaxin with an IC50 of 101 nM. Inhibition of ATX by PF-8380 led to decreased invasion and enhanced radiosensitization of GBM cells. Radiation-induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. PF-8380 can serve as a tool compound for elucidating LPA's role in inflammation.

Application

Products > Drug Discovery > Inhibitor > Other Inhibitors | Products > Drug Discovery > Inhibitor

Product Information

Catalog No.: B2693-457060
CAS No.: 1144035-53-9
Molecular Formula: C22H21Cl2N3O5
Molecular Weight: 478.33
Purity: ≥95%
Storage: Store at -20°C
Solubility: Soluble in DMSO

Source

Original product source

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