Tafamidis

Overview

Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. It is a drug for the amelioration of transthyretin-related hereditary amyloidosis. It functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein and binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR.

Application

Products > Drug Discovery > Impurities > Cardiovascular And Blood System > Tafamidis and Impurities | Products > Drug Discovery > Inhibitor

Product Information

• Catalog No.: B2693-463292
• CAS No.: 594839-88-0
• Molecular Formula: C14H7Cl2NO3
• Molecular Weight: 308.12
• Purity: >98%
• Storage: Store at -20 °C
• Solubility: Soluble in DMSO

Source

Original product source