Propargyl-PEG4-Sulfone-PEG4-t-butyl ester is a PEG linker containing a propargyl group and t-butyl protected carboxyl group acid. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. The protected acid can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media. Please contact us for GMP-grade inquiries.
Products > PEG Linkers > PEG-X-PEG | Products > PEG Linkers > PEG-X-PEG > PEG-SO2-PEG | Products > Click Chemistry Reagents > Alkyne > PEG-SO2-PEG
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