Bis-sulfone-PEG4-NHS Ester

Overview

Bis-sulfone-PEG4-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media. Please contact us for GMP-grade inquiries.

Application

PEGylation of Protein, Peptide & Oligo > Amine Reactive > PEG NHS ester | Antibody Drug Conjugates > Amine Reactive > PEG NHS ester | Drug Delivery, Surface Modification > Amine Reactive > PEG NHS ester | Products > PEG Linkers > PEG NHS ester | Products > ADC Linker, ADC Payload > Site Specific Linkers > Sulfone-PEG-NHS ester | Products > PEG Linkers > PEG NHS ester > Bis-sulfone-PEG-NHS Ester

Product Information

• Catalog No.: BP-23343
• CAS No.: 2055047-19-1
• Molecular Formula: C40H48N2O14S2
• Molecular Weight: 845
• Purity: 93%
• Storage: -20°C
• Solubility: DMSO, DCM, DMF
• Availability: In Stock

Source

Original product source