Alkyne-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potent strategy in ADC linker design. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.
Products > PEG Linkers > GGFG Linkers | Products > ADC Linker, ADC Payload > Cleavable Linkers > Val-Cit
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