Alkyne-Val-Cit-PAB-PNP

Overview

Alkyne-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potent strategy in ADC linker design. The alkyne can form triazole linkages with azide containing molecules via copper catalyzed reactions.

Application

Products > PEG Linkers > GGFG Linkers | Products > ADC Linker, ADC Payload > Cleavable Linkers > Val-Cit

Product Information

• Catalog No.: BP-26348
• CAS No.: 2748039-77-0
• Molecular Formula: C31H38N6O9
• Molecular Weight: 638.7
• Purity: 98%
• Storage: -20°C
• Solubility: DMSO, DMF
• Availability: In Stock

Source

Original product source