DBCO-PEG2-Val-Cit-PAB-MMAE

Overview

DBCO-PEG2-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups, while the Val-Cit is a protease-cleavable dipeptide which releases the MMAE warhead into cells via an elimination mechanism.

Application

Products > PEG Linkers > GGFG Linkers | Products > ADC Linker, ADC Payload > Cleavable Linkers > Val-Cit-MMAE | Products > ADC Linker, ADC Payload > ADC Payload > MMAE

Product Information

• Catalog No.: BP-40529
• CAS No.: 2845934-59-8
• Molecular Formula: C84H120N12O17
• Molecular Weight: 1570
• Purity: 95%
• Storage: -20°C
• Solubility: DMSO, DMF
• Availability: In Stock

Source

Original product source