Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus . Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC 50 of 0.02 μM. Tubercidin inhibits polymerases by incorporating DNA or RNA , thereby inhibiting DNA replication, RNA and protein synthesis. Tubercidin is a weak inhibitor of adenosine phosphorylase , and interferes with the phosphorylation of adenosine and AMP. Tubercidin has antiviral activity.
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