GSK481

Overview

GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC 50 of 1.3 nM, which inhibits Ser 166 phosphorylation in wild-type human RIP1 ( IC 50 =2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC 50 of 10 nM.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase

Product Information

• Catalog No.: HY-100131
• CAS No.: 1622849-58-4
• Molecular Formula: C21H19N3O4
• Molecular Weight: 377.39
• Purity: 98.04%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (6.62 mM); Clear solution
• Availability: In-stock

Source

Original product source