Nutlin-3a (Standard) is the analytical standard of Nutlin-3a ( HY-10029 ). This product is intended for research and analytical applications. Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute ( MDM2 ) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis . Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas.
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