PD-161570

Overview

PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC 50 of 39.9 nM and a K i of 42 nM. PD-161570 also inhibits the PDGFR , EGFR and c-Src tyrosine kinases with IC 50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF -stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC 50 s of 450 nM and 622 nM, respectively. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor.

Application

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Product Information

• Catalog No.: HY-100434
• CAS No.: 192705-80-9
• Molecular Formula: C26H35Cl2N7O
• Molecular Weight: 532.51
• Purity: 98.78%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source