(±)-Dehydroaltenusin

Overview

(±)-Dehydroaltenusin, an antibiotic , is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC 50 of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis . (±)-Dehydroaltenusin competitively inhibits the DNA template primer ( K i : 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate ( K i : 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis . (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Antibiotic

Product Information

• Catalog No.: HY-100513
• CAS No.: 34279-44-2
• Molecular Formula: C15H12O6
• Molecular Weight: 288.25
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source