Zenidolol (ICI-118551) (Standard) is the analytical standard of Zenidolol ( HY-100543 ). This product is intended for research and analytical applications. Zenidolol is a selective β2-adrenergic receptor antagonist with K i values of Zenidolol for β2, β1 and β3 adrenergic receptors of 0.7, 49.5 and 611 nM, respectively. Zenidolol exerts antitumor effects via inducing apoptosis , inhibiting tumor sphere formation, and downregulating the HIF pathway by blocking β2-AR on tumor cells. Zenidolol exhibits a unique pulmonary vessel-specific vasodilatory effect in mouse models. Zenidolol can be used as an intraocular pressure-lowering agent in ophthalmic disease research .
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