Necrosulfonamide-d 4

Overview

Necrosulfonamide -d 4 is the deuterium labeled Necrosulfonamide ( HY-100573 ). Necrosulfonamide is a MLKL and Gasdermin D ( GSDMD ) inhibitor, capable of separately inhibiting necroptosis and pyroptosis of cells. Necrosulfonamide does not affect the activation of upstream signals, but specifically inhibits the downstream executor oligomerization step. Necrosulfonamide reduces the expression of the key kinases NLRP3 and caspase-1 involved in necroptosis and pyroptosis , activate the Nrf2 pathway and the downstream antioxidant enzymes , and also downregulates a variety of inflammatory factors. Necrosulfonamide plays significant roles in various diseases such as neurodegenerative diseases (such as Parkinson’s disease), tissue damage and ischemia-reperfusion injury, inflammatory bowel disease, osteoarthritis and fracture repair, and hair loss by regulating two important programmed necrosis pathways.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Endocrinology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Mixed Lineage Kinase | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > Integrin | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > Heme Oxygenase (HO) | Products > Signaling Pathways > Isotope-Labeled Compounds

Product Information

• Catalog No.: HY-100573S
• CAS No.: 1795144-22-7
• Molecular Formula: C18H11D4N5O6S2
• Molecular Weight: 465.50
• Purity: 99.65%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source