Didesmethyl cariprazine-d 8

Overview

Didesmethyl cariprazine -d 8 is the deuterium labeled Didesmethyl cariprazine ( HY-100658 ). Didesmethyl cariprazine is an orally active, BBB-permeable metabolite of Cariprazine ( HY-14763 ). Didesmethyl cariprazine is a partial agonist at the D2 and D3 receptors, full agonist at the 5-HT1A receptor, and antagonist at the human 5-HT2B receptor (K i : 1.41 nM (human D2L), 0.056 nM (human D3), 1.7 nM (human 5-HT1A), 0.52 nM (human 5-HT2B)). Didesmethyl cariprazine dose-dependently inhibits the spontaneous activity of rat midbrain dopaminergic neurons.

Application

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Product Information

• Catalog No.: HY-100658S
• CAS No.: 1308279-08-4
• Molecular Formula: C19H20D8Cl2N4O
• Molecular Weight: 407.41
• Purity: 99.40%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source