(R)-GNE-140

Overview

(R)-GNE-140 is a potent inhibitor of lactate dehydrogenase ( LDH ) A, B and C, with IC 50 values of 3, 5 and 5 nM against LDHA, LDHB, LDHC , respectively. (R)-GNE-140 blocks the conversion of pyruvate to lactate, reduces lactate production and histone lysine lactylation, and inhibits glycolysis. (R)-GNE-140 attenuates cardiac hypertrophy, alleviates PM 2.5 -induced pulmonary inflammation and fibrosis, blocks MRSA-induced Arg1 expression. (R)-GNE-140 is applicable to research related to pathological cardiac hypertrophy, pulmonary fibrosis, MRSA infection and pancreatic cancer .

Application

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Product Information

• Catalog No.: HY-100742A
• CAS No.: 2003234-63-5
• Molecular Formula: C25H23ClN2O3S2
• Molecular Weight: 499.04
• Purity: 99.73%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
• Solubility: ≥ 2.5 mg/mL (5.01 mM); Clear solution
• Availability: In-stock

Source

Original product source