TX1-85-1

Overview

TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC 50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand , which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.

Application

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Product Information

• Catalog No.: HY-100848
• CAS No.: 1603845-32-4
• Molecular Formula: C32H36N8O3
• Molecular Weight: 580.68
• Purity: 99.65%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 0.38 mg/mL (0.65 mM); Clear solution
• Availability: In-stock

Source

Original product source