KI696 isomer

Overview

KI696 isomer is an isomer of KI696 ( HY-101140 ). KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human K d value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Pulmonary Disease | Products > Signaling Pathways > Others | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Drug Isomer

Product Information

• Catalog No.: HY-101140A
• CAS No.: 1799974-69-8
• Molecular Formula: C28H30N4O6S
• Molecular Weight: 550.63
• Purity: 98.37%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution
• Availability: In-stock

Source

Original product source