JNJ-39758979 (Standard)

Overview

JNJ-39758979 (Standard) is the analytical standard of JNJ-39758979 ( HY-101189 ). This product is intended for research and analytical applications. JNJ-39758979 , a chemical probe, is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity.

Application

Products | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Others | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Histamine Receptor | Products > Signaling Pathways > Reference Standards

Product Information

• Catalog No.: HY-101189R
• CAS No.: 1046447-90-8
• Molecular Formula: C11H19N5
• Molecular Weight: 221.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source