MPT0B392 (Standard)

Overview

MPT0B392 (Standard) is the analytical standard of MPT0B392 ( HY-101287 ). This product is intended for research and analytical applications. MPT0B392 , an orally active quinoline derivative, induces c-Jun N-terminal kinase ( JNK ) activation, leading to apoptosis . MPT0B392 inhibits tubulin polymerization and triggers induction of the mitotic arrest, followed by mitochondrial membrane potential loss and caspases cleavage by activation of JNK and ultimately leads to apoptosis . MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line.

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Others | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > JNK

Product Information

• Catalog No.: HY-101287R
• CAS No.: 1346169-92-3
• Molecular Formula: C19H20N2O6S
• Molecular Weight: 404.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source