PF-6274484

Overview

PF-6274484 is a potent EGFR inhibitor with K i s of 0.14 nM and 0.18 nM for EGFR-L858R/T790M and WT EGFR , respectively. PF-6274484 inhibits EGFR-L858R/T790M autophosphorylation in H1975 tumor cells and EGFR WT in A549 tumor cells with IC 50 s of 6.6 and 5.8 nM, respectively.

Application

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Product Information

• Catalog No.: HY-101450
• CAS No.: 1035638-91-5
• Molecular Formula: C18H14ClFN4O2
• Molecular Weight: 372.78
• Purity: 98.76%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.08 mg/mL (5.58 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source