RG-12525 (Standard)

Overview

RG-12525 (Standard) is the analytical standard of RG-12525 ( HY-101676 ). This product is intended for research and analytical applications. RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4 , with a Ki value of 0.5 μM.

Application

Products | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Others | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Leukotriene Receptor | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > PPAR

Product Information

• Catalog No.: HY-101676R
• CAS No.: 120128-20-3
• Molecular Formula: C25H21N5O2
• Molecular Weight: 423.47
• Purity: 95%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source