GSK-872 hydrochloride

Overview

GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC 50 of 1.8 nM, and inhibits kinase activity with an IC 50 of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase

Product Information

• Catalog No.: HY-101872A
• CAS No.: 2703752-81-0
• Molecular Formula: C19H18ClN3O2S2
• Molecular Weight: 419.95
• Purity: 98.85%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
• Solubility: ≥ 0.21 mg/mL (0.50 mM); Clear solution
• Availability: In-stock

Source

Original product source