RG3039

CAS No.：1005504-62-0
Grade：99.30%
Formula：C21H23Cl2N5O
M.W.：432.35

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

RG3039 (PF-06687859) is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC 50 of 4.2 nM against hDcpS. RG3039 inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 extends survival and improves function in spinal muscular atrophy mice. RG3039 is applicable to research related to spinal muscular atrophy.

Application

Products | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Muscle Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > PROTAC | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Ligands for Target Protein for PROTAC

Product Information

Catalog No.: HY-102020
CAS No.: 1005504-62-0
Molecular Formula: C21H23Cl2N5O
Molecular Weight: 432.35
Purity: 99.30%
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
Availability: In-stock

Source

Original product source

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