BMS-599626

Overview

BMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC 50 s of 20 and 30 nM, respectively. BMS-599626 displays ~8-fold less potent to HER4 (IC 50 =190 nM), >100-fold to VEGFR2, c-Kit , Lck , MEK . BMS-599626 inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.

Application

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Product Information

• Catalog No.: HY-10251
• CAS No.: 714971-09-2
• Molecular Formula: C27H27FN8O3
• Molecular Weight: 530.55
• Purity: 98.56%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.75 mg/mL (5.18 mM); Clear solution
• Availability: In-stock

Source

Original product source