I-XW-053

Overview

I-XW-053 is a specific anti- HIV-1 capsid inhibitor ( IC 50 =164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD ( K d =66.3 μM), I-XW-053 disrupts capsid function and reduces polymerization levels. I-XW-053 effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 can be widely used in studies related to HIV-1 infection.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > HIV Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > HIV | Products > Signaling Pathways > Reverse Transcriptase

Product Information

• Catalog No.: HY-103078
• CAS No.: 5496-35-5
• Molecular Formula: C22H16N2O2
• Molecular Weight: 340.38
• Purity: 99.71%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (14.69 mM); Clear solution
• Availability: In-stock

Source

Original product source