GATA4-NKX2-5-IN-1

Overview

GATA4-NKX2-5-IN-1 (Compound 3) dose-dependently inhibits the GATA4–NKX2-5 transcriptional synergy with an IC 50 of 3 μM. GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Cardiovascular Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > IKZF Family

Product Information

• Catalog No.: HY-103484
• CAS No.: 544681-96-1
• Molecular Formula: C21H23N3O2
• Molecular Weight: 349.43
• Purity: 99.24%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.08 mg/mL (5.95 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source