LY456236

Overview

LY456236 is a selective, non-competitive and orally active antagonist of glutamate receptor 1 ( mGlu1 ), which can inhibit phosphatidylinositol hydrolysis with an IC 50 of 0.145 μM. LY456236 can also inhibit EGFR , with an IC 50 of 0.918 μM. LY456236 blocks cell proliferation by inhibiting the MAPK pathway, reversing the anti- apoptotic effect of DHPG ( HY-12598A ). LY456236 can be used in epilepsy research.

Application

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Product Information

• Catalog No.: HY-103566
• CAS No.: 338736-46-2
• Molecular Formula: C16H16ClN3O2
• Molecular Weight: 317.78
• Purity: 99.57%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source