dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF ( HY-114872 ) of FKBP12 , the Thalidomide based Cereblon ligand and a linker. (Pink: FKBP12 ligand ( HY-114872 ); Blue: E3 ligase ligand; Black: linker).
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