NAZ2329 (Standard)

Overview

NAZ2329 (Standard) is the analytical standard of NAZ2329 ( HY-103693 ). This product is intended for research and analytical applications. NAZ2329 , the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC 50 =7.5 µM for hPTPRZ1) and PTPRG (IC 50 =4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC 50 of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC 50 of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties.

Application

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Product Information

• Catalog No.: HY-103693R
• CAS No.: 2809469-05-2
• Molecular Formula: C21H18F3NO4S3
• Molecular Weight: 501.56
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source