Samuraciclib hydrochloride

Overview

Samuraciclib hydrochloride (CT7001 hydrochloride) is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC 50 of 41 nM. Samuraciclib hydrochloride displays 45-, 15-, 230- and 30-fold selectivity over CDK1 , CDK2 (IC 50 of 578 nM), CDK5 and CDK9 , respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI 50 values between 0.2-0.3 µM. Samuraciclib hydrochloride has anti-tumor effects.

Application

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Product Information

• Catalog No.: HY-103712A
• CAS No.: 1805789-54-1
• Molecular Formula: C22H31ClN6O
• Molecular Weight: 430.97
• Purity: 99.90%
• Storage: 4°C, stored under nitrogen, away from moisture * In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen, away from moisture)
• Solubility: ≥ 2.5 mg/mL (5.80 mM); Clear solution
• Availability: In-stock

Source

Original product source