CEP-1347 is an inhibitor of the JNK/SAPK pathway with neuroprotective effects. CEP-1347 blocks JNK1 activation induced by members of the mixed lineage kinase (MLK) family (MLK3, MLK2, MLK1, dual leucine zipper kinase, and leucine zipper kinase). As an inhibitor of MDM4 , CEP-1347 can more effectively inhibit the growth of glioma cells expressing wild-type p53 .
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PROTAC | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Mixed Lineage Kinase | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Ligands for Target Protein for PROTAC
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