Valproic acid

Overview

Valproic acid (VPA) is an orally active HDAC inhibitor, with IC 50 in the range of 0.5 and 2 mM. Valproic acid inhibits HDAC1 ( IC 50 , 400 μM), and induces proteasomal degradation of HDAC2 . Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the epilepsy, bipolar disorder, metabolic disease , HIV infection and prevention of migraine headaches.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Small Cell Lung Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Organoid | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Mitophagy | Products > Signaling Pathways > HIV | Products > Signaling Pathways > Notch | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Endogenous Metabolite

Product Information

• Catalog No.: HY-10585
• CAS No.: 99-66-1
• Molecular Formula: C8H16O2
• Molecular Weight: 144.21
• Purity: 99.90%
• Storage: Store at room temperature 3 years. In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (17.34 mM); Clear solution
• Availability: In-stock

Source

Original product source