TP-9201 is a platelet glycoprotein ( GP ) IIb/IIIa receptor antagonist. TP-9201 inhibits the interaction between GPIIb/IIIa and fibrinogen, thereby suppressing platelet aggregation. TP-9201 exhibits similar inhibitory activity on adenosine diphosphate (ADP) ( HY-W010918 )-induced platelet aggregation in humans, baboons, and dogs ( IC 50 = 1-3 μM), while showing lower activity in rabbits ( IC 50 = 45 μM) and rats ( IC 50 = 20 μM). TP-9201can be used in studies related to the prevention of rethrombosis after arterial thrombolysis.
Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > P-glycoprotein
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