TRIMETHYLPHOSPHINE OXIDE

CAS No.：676-96-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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TRIMETHYLPHOSPHINE OXIDE Basic information

Product Name:	TRIMETHYLPHOSPHINE OXIDE
Synonyms:	TRIMETHYLPHOSPHINE OXIDE;(CH3)3PO;(Dimethyl-phosphinoyl)-methane;Phosphine oxide, trimethyl-;dimethylphosphorylmethane;Phosphine oxide,trimethyl- (6CI,8CI,9CI);Trimethylphosphinoxid;Oseltamivir Impurity 178
CAS:	676-96-0
MF:	C3H9OP
MW:	92.08
EINECS:	211-633-9
Product Categories:	TMPO
Mol File:	676-96-0.mol

TRIMETHYLPHOSPHINE OXIDE Chemical Properties

Melting point	140-141°C
Boiling point	194℃
density	0.900
Fp	71℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in polar organic solvents.
form	Crystalline

Safety Information

Risk Statements	22-36/37/38
Safety Statements	26-36
HS Code	29319090

MSDS Information

Provider	Language
ALFA	English

TRIMETHYLPHOSPHINE OXIDE Usage And Synthesis

Uses

Trimethylphosphine oxide is a common side product in organic synthesis, including the Wittig, Staudinger, Mitsunobu reactions and also in the manufacture of triphenylphosphine. It is a popular reagent to induce the crystallization of various chemical compounds. It acts as an excellent ligand for hard metal centers. It can react with 9-methyl-9-azonianthracene methyl sulfate to get (10-methyl-9,10-dihydro-acridin-9-yl)-phosphonic acid dimethyl ester using sodium iodide and acetonitrile as solvent.

TRIMETHYLPHOSPHINE OXIDE Preparation Products And Raw materials

Raw materials	cadmium dioleate-->Trimethylphosphine selenide-->TRIMETHYLPHOSPHINE SULFIDE-->Trimethylphosphine-->Iodomethane-->Methylmagnesium chloride
Preparation Products	Formic acid-->Carbon disulfide

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