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| Halobetasol propionate Basic information |
| Product Name: | Halobetasol propionate | | Synonyms: | ulobetasol propionate;HALOBETASOL PROPIONATE;BMY-30056;CGP-14458;Uiobetasol Propionate;Ultravate;21-chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate;6 alpha-fluoroclobetasol 17-propionate | | CAS: | 66852-54-8 | | MF: | C25H31ClF2O5 | | MW: | 484.96 | | EINECS: | 686-247-0 | | Product Categories: | Inhibitors;Steroids | | Mol File: | 66852-54-8.mol |
| Halobetasol propionate Chemical Properties |
| Melting point | 213-215°C | | Boiling point | 570.7±50.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Dioxane (Sparingly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 12.55±0.70(Predicted) | | color | White to Off-White | | CAS DataBase Reference | 66852-54-8(CAS DataBase Reference) |
| Halobetasol propionate Usage And Synthesis |
| Description | Halobetasol propionate is a new ultra-potent topical corticosteroid exhibiting both
antiinflammatory and antihyperplasia properties. The compound is recommended for
the treatment of moderate to severe corticosteroid-responsive dermatoses and appears
to be particularly effective in patients with plaque psoriasis. | | Description | Halobetasol propionate is a synthetic glucocorticoid. It inhibits dermatitis induced by ultraviolet light in guinea pigs (ED50 = 1.45 μg/animal) and by oxazolone in mice (ED50 = 0.8 μg/animal). Halobetasol propionate also has anti-inflammatory effects on croton oil-induced ear edema in rats (ED50s = 10 μg/ml and 0.5 μg/ear) and mice (ED50s = 1.2 and <0.32 μg/ear after 6 and 24 hours of treatment, respectively). Topical formulations containing halobetasol propionate have been used for inflammatory and pruritic dermatitis. | | Chemical Properties | White Solid | | Originator | Ciba-Geigy (Switzerland) | | Uses | Anti-inflammatory; a dermatologic agent commonly used to treat psoriasis | | Brand name | Ultravate (Westwood-Squibb). |
| Halobetasol propionate Preparation Products And Raw materials |
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