MK 287

Overview

MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor ( PAFR ). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED 50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease , such as thrombosis.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Platelet-activating Factor Receptor (PAFR)

Product Information

• Catalog No.: HY-106899
• CAS No.: 135947-75-0
• Molecular Formula: C25H34O9S
• Molecular Weight: 510.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source