PD 161374 is an inhibitor targeting the HIV-1 nucleocapsid protein NCp7 . PD 161374 primarily acts on the early stages of viral replication, inhibiting the completion of reverse transcription without affecting viral entry or later assembly. PD 161374 remains active against HIV-1 , HIV-2 , SIV, and drug-resistant strains. PD 161374 can be used to study antiretroviral agents.
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