Abrocitinib (Standard)

Overview

Abrocitinib (Standard) is the analytical standard of Abrocitinib. This product is intended for research and analytical applications. Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC 50 s of 29 and 803 nM for JAK1 and JAK2 , respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 ( IC 50 , 1.253 μM), and inhibits phosphorylation of STAT1 , STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > JAK

Product Information

• Catalog No.: HY-107429R
• CAS No.: 1622902-68-4
• Molecular Formula: C14H21N5O2S
• Molecular Weight: 323.41
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source