SirReal1-O-propargyl

Overview

SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 ( Sirt2 ) inhibitor, with an IC 50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Ligands for Target Protein for PROTAC | Products > Signaling Pathways > Sirtuin

Product Information

• Catalog No.: HY-107453
• CAS No.: 1862237-99-7
• Molecular Formula: C21H20N4O2S2
• Molecular Weight: 424.54
• Purity: 99.98%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Source

Original product source